|
rs4794136
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variation c.1569C>T (XYLT-II) occurs with a significantly higher frequency in younger OA patients in comparison with the older ones (P<0.001) and the controls (P<0.02).
|
16376579 |
2006 |
|
rs777761378
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variation c.1569C>T (XYLT-II) occurs with a significantly higher frequency in younger OA patients in comparison with the older ones (P<0.001) and the controls (P<0.02).
|
16376579 |
2006 |
|
rs2908004
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, two SNPs (rs2908004 and rs1799986) are associated with the decreased risk of OA by regulating the Wnt pathway.
|
31560818 |
2019 |
|
rs731236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs731236 polymorphism is associated with the risk of primary OA of the knee in Mexican Mestizo population.
|
30657057 |
2018 |
|
rs2248393
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs2626053
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.
|
22763110 |
2012 |
|
rs41310883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A nonsynonymous single nucleotide variant rs41310883 (c.524C>T, p.Thr175Met) in TUFT1 gene was found to co-segregate perfectly with MTP I OA.
|
28410428 |
2017 |
|
rs1149620
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs1061622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Tumor necrosis factor receptor 2 M196R polymorphism in rheumatoid arthritis and osteoarthritis: relationship with sTNFR2 levels and clinical features.
|
16871413 |
2006 |
|
rs1564861
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the genetic model analysis, we found that rs1905786, rs1032128, rs3134058, rs11573828, rs11573849, rs3134056, and rs1564861 were associated with an increased or decreased risk of knee OA before adjusted by sex and age.
|
30972968 |
2019 |
|
rs1032128
|
|
|
0.010 |
GeneticVariation |
BEFREE |
And after adjustment, three SNPs (rs1485286, rs1905786, and rs1032128) were identified to have a negative effect on knee OA.
|
30972968 |
2019 |
|
rs1905786
|
|
|
0.010 |
GeneticVariation |
BEFREE |
And after adjustment, three SNPs (rs1485286, rs1905786, and rs1032128) were identified to have a negative effect on knee OA.
|
30972968 |
2019 |
|
rs1800629
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The frequencies of the allele 'A' of rs1800629 were 16% and 8.85% in OA cases and in controls, respectively, and thus the -308A allele had a 1.9612-fold (95% CI = 1.3323-2.8869, P < 0.001) increased risk for OA as compared to the -308G allele.
|
23748461 |
2013 |
|
rs1800629
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The purpose of the present case-control study was to investigate a possible association of four cytokine single nucleotide polymorphisms (SNPs), IL-4R -3223C>T (rs2057768), IL-8 -251T>A (rs4073), IL-10 -1082A>G (rs1800896) and TNF -A-308G>A (rs1800629) with OA susceptibility.
|
30186498 |
2018 |
|
rs1800629
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, TNF-α rs1800629 polymorphism confers susceptibility to OA, especially among Asians.
|
29846433 |
2018 |
|
rs361525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no significant differences were found in the genotype and allele frequencies for rs361525 between OA and HC groups.
|
23748461 |
2013 |
|
rs10502437
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs352140
|
|
|
0.010 |
GeneticVariation |
BEFREE |
T-1486C was significantly associated with OA in both populations with G1635A of TLR-9 gene was found to be significantly associated with OA when the two populations were combined.
|
21748790 |
2012 |
|
rs715572
|
|
|
0.020 |
GeneticVariation |
BEFREE |
TIMP3 rs715572G/A is a candidate protective gene for severe knee OA.</span>
|
26068512 |
2015 |
|
rs715572
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The minor G allele of rs650108 was associated with OA risk in a recessive model (<i>p</i> = 0.034, OR = 1.82, 95%CI = 1.04-3.18), while the minor A allele of rs715572 was associated with OA risk in a recessive model (<i>p =</i> 0.030, OR = 1.88, 95%CI = 1.05-3.34).
|
29137364 |
2017 |
|
rs75621460
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs1800470
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We have shown that a T(869)-->C polymorphism of the transforming growth factor-beta1 (TGF-beta1) gene, which results in a Leu-->Pro substitution at amino acid 10, is associated with bone mineral density in Japanese adolescents and postmenopausal women, with genetic susceptibility to osteoporosis or spinal osteoarthritis, and with the outcome of treatment for osteoporosis with active vitamin D. I here review our recent studies, which have provided insight into the function of TGF-beta1 as well as into the role of genetic factors in the development of osteoporosis and osteoarthritis.
|
10996011 |
2000 |
|
rs1800470
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Association of TGFB1 29C/T and IL6 -572G/C polymorphisms with developmental hip dysplasia: a case-control study in adults with severe osteoarthritis.
|
25603974 |
2015 |
|
rs1982073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Ethnicity and genotyping method-stratified analysis under both models implied that the rs1982073 C>T polymorphism was positively correlated with the risk of fracture, OP, and OA among Asians under detection via the non-PCR-RFLP method.
|
25501632 |
2016 |
|
rs3771501
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |